hyperacetylation
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
August 18, 2011 Publications, Featured
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, A Stančáková, E Goetzman, MM Lam, B Schwer, RD Stevens, MJ Muehlbauer, S Kakar, NM Bass, J Kuusisto, M Laakso, FW Alt, CB Newgard, RV Farese Jr., CR Kahn and E Verdin (2011) SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. Molecular Cell, In pressRead More...
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
December 01, 2010 Publications
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. Dec 1;12(6):662-7.Read More...
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
December 01, 2010 Publications, Featured
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. (2010) SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. Dec 1;12(6):654-61.Read More...Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
October 08, 2007 Publications
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weisssman S, Verdin E, Schwer B (2007). Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation. Mol. Cell Biol. Epub Oct. 8Read More...Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
August 22, 2011 Publications
Enxuan Jing, Brice Emanuelli, Matthew D. Hirschey, Jeremie Boucher, Kevin Y. Lee, David Lombard, Eric M. Verdin, and C. Ronald Kahn (2011) Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. PNAS, In pressRead More...Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice
March 02, 2012 Publications
Kristofer S Fritz, James Joseph Galligan, Matthew Hirschey, Eric Verdin, and Dennis R. Petersen (2012) Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice. Journal of Proteome Research. 2012 11(3):1633-43.Read More...