Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases
Hirschey MD (2011) Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases. Cell Metab. Dec 7;14(6):718.
Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)+-dependent deacetylases and are important modulators of genomic stability, energy metabolism and stress resistance. Two new studies by Du et al (2011) and Peng et al (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of post-translational modifications targeted by the sirtuins beyond acetylation.