Publications
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
February 01, 2013
P Gut, B Baeza-Raja, O Andersson, L Hasenkamp, D Hesselson, K Akassoglou, E Verdin, MD Hirschey and DYR Stainier. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chem. Biol. (2013) 9, 97–104Read More...SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome
February 01, 2013
Michelle F Green and Matthew D Hirschey (2012) SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome. Journal of Gerontology: Biological Science. 2013 68(2):105-7.Read More...
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
January 11, 2013
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, CA Grueter, H Lim, LR Saunders, RD Stevens, CB Newgard, RV Farese Jr., R de Cabo, S Ulrich, K Akassoglou, E Verdin (2012) Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor. Science, 2013 Jan 11;339(6116):211-4Read More...HINT2 and Fatty Liver Disease: Mitochondrial Protein Hyperacetylation Gives A Hint?
September 18, 2012
KA Anderson*, D Wang* and MD Hirschey. HINT2 and Fatty Liver Disease: Mitochondrial Protein Hyperacetylation Gives A Hint? Hepatology (2012) In pressRead More...Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression
June 06, 2012
Joel T. Haas, Ji Miao, Dipanjan Chanda, Yanning Wang, Enpeng Zhao, Mary E. Haas, Matthew Hirschey, B. Vaitheesvaran, Robert V. Farese, Irwin J. Kurland, Mark Graham, Rosanne Crooke, Fabienne Foufelle, Sudha B. Biddinger (2012) Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression. Cell Metab. Jun 6;15(6):873.Read More...Mitochondrial protein acetylation regulates metabolism
June 01, 2012
KA Anderson and MD Hirschey (2012) Mitochondrial protein acetylation regulates metabolism. Essays in Biochemistry, 52:23-35.Read More...Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice
March 02, 2012
Kristofer S Fritz, James Joseph Galligan, Matthew Hirschey, Eric Verdin, and Dennis R. Petersen (2012) Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice. Journal of Proteome Research. 2012 11(3):1633-43.Read More...
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
January 29, 2012
Ryan S. Streeper*, Carrie A. Grueter*, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Matthew D. Hirschey, Eric Verdin, and Robert V. Farese, Jr. (2012) Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging, 4 (1), 13-27Read More...
SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism
December 31, 2011
MD Hirschey, T Shimazu, J-Y Huang, B Schwer, and E Verdin (2011) SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism. Metabolism and Disease (Cold Spring Harbor Symposia on Quantitative Biology) 76: 267-77Read More...
Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases
December 07, 2011
Hirschey MD (2011) Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases. Cell Metab. Dec 7;14(6):718.Read More...Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
August 22, 2011
Enxuan Jing, Brice Emanuelli, Matthew D. Hirschey, Jeremie Boucher, Kevin Y. Lee, David Lombard, Eric M. Verdin, and C. Ronald Kahn (2011) Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. PNAS, In pressRead More...SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
August 18, 2011
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, A Stančáková, E Goetzman, MM Lam, B Schwer, RD Stevens, MJ Muehlbauer, S Kakar, NM Bass, J Kuusisto, M Laakso, FW Alt, CB Newgard, RV Farese Jr., CR Kahn and E Verdin (2011) SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. Molecular Cell, In pressRead More...
SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
June 19, 2011
MD Hirschey*, T Shimazu*, JA Capra*, KS Pollard, and E Verdin. (2011) SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2. AGING 3, 1–8Read More...
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
December 01, 2010
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. Dec 1;12(6):662-7.Read More...
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
December 01, 2010
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. (2010) SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. Dec 1;12(6):654-61.Read More...Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
September 20, 2010
Verdin E, Hirschey MD, Finley LW, Haigis MC. (2010) Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. Dec;35(12):669-75. Epub 2010 Sep 20.Read More...
Acetate metabolism and aging: An emerging connection
May 15, 2010
Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. (2010) Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. Jul-Aug;131(7-8):511-6. Epub 2010 May 15.Read More...SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
March 04, 2010
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature, 464, 121-125Read More...Mitochondrial Sirtuins
January 07, 2010
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. (2010) Mitochondrial Sirtuins. Biochim Biophys Acta. 2010 Jan 7.Read More...
Acetylation of mitochondrial proteins
May 06, 2009
Hirschey MD, Shimazu T, Huang JY, Verdin E. (2009) Acetylation of mitochondrial proteins. Methods Enzymol. 2009;457:137-47.Read More...
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
October 08, 2007
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weisssman S, Verdin E, Schwer B (2007). Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation. Mol. Cell Biol. Epub Oct. 8Read More...Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots
May 25, 2006
Hirschey MD, Han YJ, Stucky GD, Butler A. (2006) Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots. J. Bio. Inorg. Chem. Jul;11(5):663-9. Epub 2006 May 25.Read More...