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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
January 11, 2013
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, CA Grueter, H Lim, LR Saunders, RD Stevens, CB Newgard, RV Farese Jr., R de Cabo, S Ulrich, K Akassoglou, E Verdin (2012) Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor. Science, 2013 Jan 11;339(6116):211-4Read More...Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases
December 07, 2011
Hirschey MD (2011) Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases. Cell Metab. Dec 7;14(6):718.Read More...SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
August 18, 2011
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, A Stančáková, E Goetzman, MM Lam, B Schwer, RD Stevens, MJ Muehlbauer, S Kakar, NM Bass, J Kuusisto, M Laakso, FW Alt, CB Newgard, RV Farese Jr., CR Kahn and E Verdin (2011) SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome. Molecular Cell, In pressRead More...
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
December 01, 2010
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. (2010) SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. Dec 1;12(6):654-61.Read More...SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
March 04, 2010
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature, 464, 121-125Read More...