Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
February 01, 2013 Publications
P Gut, B Baeza-Raja, O Andersson, L Hasenkamp, D Hesselson, K Akassoglou, E Verdin, MD Hirschey and DYR Stainier. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chem. Biol. (2013) 9, 97–104Read More...SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome
February 01, 2013 Publications, Perspective
Michelle F Green and Matthew D Hirschey (2012) SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome. Journal of Gerontology: Biological Science. 2013 68(2):105-7.Read More...
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
January 11, 2013 Publications, Featured
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, CA Grueter, H Lim, LR Saunders, RD Stevens, CB Newgard, RV Farese Jr., R de Cabo, S Ulrich, K Akassoglou, E Verdin (2012) Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor. Science, 2013 Jan 11;339(6116):211-4Read More...HINT2 and Fatty Liver Disease: Mitochondrial Protein Hyperacetylation Gives A Hint?
September 18, 2012 Publications, Perspective
KA Anderson*, D Wang* and MD Hirschey. HINT2 and Fatty Liver Disease: Mitochondrial Protein Hyperacetylation Gives A Hint? Hepatology (2012) In pressRead More...Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression
June 06, 2012 Publications
Joel T. Haas, Ji Miao, Dipanjan Chanda, Yanning Wang, Enpeng Zhao, Mary E. Haas, Matthew Hirschey, B. Vaitheesvaran, Robert V. Farese, Irwin J. Kurland, Mark Graham, Rosanne Crooke, Fabienne Foufelle, Sudha B. Biddinger (2012) Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression. Cell Metab. Jun 6;15(6):873.Read More...Mitochondrial protein acetylation regulates metabolism
June 01, 2012 Publications
KA Anderson and MD Hirschey (2012) Mitochondrial protein acetylation regulates metabolism. Essays in Biochemistry, 52:23-35.Read More...Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice
March 02, 2012 Publications
Kristofer S Fritz, James Joseph Galligan, Matthew Hirschey, Eric Verdin, and Dennis R. Petersen (2012) Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice. Journal of Proteome Research. 2012 11(3):1633-43.Read More...
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
January 29, 2012 Publications
Ryan S. Streeper*, Carrie A. Grueter*, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Matthew D. Hirschey, Eric Verdin, and Robert V. Farese, Jr. (2012) Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging, 4 (1), 13-27Read More...